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Mali, Audumbar
- Zero order and Area Under Curve Spectrophotometric Methods for Determination of Riboflavin in Pharmaceutical Formulation
Abstract Views :198 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 35-40Abstract
Simple, fast and reliable spectrophotometric methods were developed for determination of Riboflavin in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 445 nm and the area under the curve method values measured at 420-473nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Riboflavin using 5-25μg/ml (r²=0.999 and r²=0.999) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Riboflavin in tablets.Keywords
Riboflavin, UV Visible Spectrophotometry, AUC, Method Validation, Zero Order Method.
- Simultaneous UV Spectrophotometric Methods for Estimation of Cefixime Trihydrate and Ofloxacin in Bulk and Tablet Dosage Form
Abstract Views :168 |
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Authors
Audumbar Mali
1,
Santosh Jadhav
1,
Rahul Gorad
2,
Aamer Quazi
2,
Ritesh Bathe
1,
Manojkumar Patil
1,
Ashpak Tamboli
3
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 2 (2016), Pagination: 100-106Abstract
Simple, precise, economical, fast and reliable two UV methods have been developed for the simultaneous estimation of Cefixime Trihydrate and Ofloxacin in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 287 nm and 296 nm for Cefixime Trihydrate and Ofloxacin respectively. Method B is area under curve (AUC), in the wavelength range of 265-301 nm for Cefixime Trihydrate and277-320nm for Ofloxacin. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for Cefixime Trihydrate and 5-25 μg/ml for Ofloxacin. The accuracy of the methods was assessed by recovery studies and was found to be 98.83% and 100.12% for Cefixime Trihydrate and 102.71 % and 99.01 % Ofloxacin by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Cefixime Trihydrate and Ofloxacin in commercial pharmaceutical dosage form.Keywords
Cefixime Trihydrate, Ofloxacin, Simultaneous Estimation, Accuracy, Absorbance Maxima Method, Area under Curve.- Simultaneous UV Spectrophotometric Methods for Estimation of Ranitidine and Domperidonein Bulk and Tablet Dosage Form
Abstract Views :175 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Shri D.D. Vispute College of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Raigad-410206, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Shri D.D. Vispute College of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Raigad-410206, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 1 (2016), Pagination: 5-10Abstract
Two simple, precise, economical, fast and reliable UV methods have been developed for the simultaneous estimation of Ranitidine and Domperidone in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 314 nm and 286 nm for Ranitidine and Domperidone respectively. Method B is area under curve (AUC), in the wavelength range of 269-340nm for Ranitidine and 262-307nm for Domperidone. Linearity for detector response was observed in the concentration range of 5-25μg/ml for Ranitidine and 5-25 μg/ml for Domperidone. The accuracy of the methods was assessed by recovery studies and was found to be 99.18% and 100.21% for Ranitidine and 100.19% and 101.57% Domperidone by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Ranitidine and Domperidone in commercial pharmaceutical dosage form.Keywords
Ranitidine, Domperidone, Simultaneous Estimation, Precision, Absorbance Maxima Method, Area under Curve.- Simultaneous Determination of Paracetamol and Domperidone in Pharmaceutical Dosage Form by First Order Derivative UV Spectrophotometry
Abstract Views :188 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Shri D.D. Vispute college of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Mumbai, Maharashtra, IN
3 Department of Pharmacognosy and Phytochemistry, Shri D.D. Vispute college of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Mumbai, Maharashtra, IN
4 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Shri D.D. Vispute college of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Mumbai, Maharashtra, IN
3 Department of Pharmacognosy and Phytochemistry, Shri D.D. Vispute college of Pharmacy and Research Centre, Devad-Vichumbe, New Panvel, Mumbai, Maharashtra, IN
4 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 6, No 1 (2016), Pagination: 22-26Abstract
Derivative spectrophotometry offers a useful approach for the analysis of drugs in multi-component formulation. In this study a first order derivative spectrophotometric method is applied for the simultaneous determination of Paracetamol and Domperidone in Tablet dosage form. The measurements were carried out at wavelengths of 262 and 297 nm for Paracetamol and Domperidone respectively. The method was found to be linear (r2=0.999) in the range of 5-25 μg/ml for Paracetamol in the presence of 20μg/ml of Domperidone at 262 nm. The linear correlation (r2=0.999) was obtained in the range of 5-25μg/ml for Domperidone in the presence of 20μg/ml of Paracetamol at 297 nm. The method was successfully used for simultaneous determination of Paracetamol and Domperidone in tablet dosage form without any interference from excipients and prior separation.Keywords
Paracetamol, Domperidone, UV Visible Spectrophotometry, Method Validation, First Order Derivative Method.- Simultaneous UV Spectrophotometric Methods for Estimation of Carvedilol and Hydrochlorothiazide in Bulk and Tablet Dosage Form
Abstract Views :211 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Dist. Latur-413512 Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Channabasweshwar Pharmacy College, Latur, Dist. Latur-413512 Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 1 (2016), Pagination: 15-20Abstract
Two simple, precise, economical, fast and reliable two UV methods have been developed for the simultaneous estimation of Carvediloland Hydrochlorothiazide in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 290 nm and 271 nm for Carvedilol and Hydrochlorothiazide respectively. Method B is area under curve (AUC), in the wavelength range of 260-308 nm for Carvedilol and 2246-292 nm for Hydrochlorothiazide. Linearity for detector response was observed in the concentration range of 5-25μg/ml for Carvedilol and 5-25 μg/ml for Hydrochlorothiazide. The accuracy of the methods was assessed by recovery studies and was found to be 100.13% and 102.28% for Carvedilol and 99.04% and 99.89% Hydrochlorothiazide by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Carvedilol and Hydrochlorothiazide in commercial pharmaceutical dosage form.Keywords
Carvedilol, Hydrochlorothiazide, Simultaneous Estimation, Accuracy, Absorbance Maxima Method, Area under Curve.- Development and Estimation of Pyridoxine HCl in Bulk and Formulation by Second Order Derivative Area under Curve UV-Spectrophotometric Methods
Abstract Views :185 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, ASPM’S K. T. Patil College of Pharmacy, Osmanabad-413501, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 2 (2016), Pagination: 106-112Abstract
Simple, novel, fast, accurate and reliable spectrophotometric methods were developed for determination of Pyridoxine HCl in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Dist. water. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 301-319nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Pyridoxine HCl using 5-25μg/ml (r²=0.9966) for second order derivative Area under Curve spectrophotometric method. The proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Pyridoxine HCl in pharmaceutical formulations.Keywords
Pyridoxine HCI, Second Order Derivative, Area under Curve (AUC), Precision, Accuracy.- Simultaneous UV Spectrophotometric Methods for Estimation of Paracetamol and Domperidone in Bulk and Tablet Dosage Form
Abstract Views :205 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, IN
3 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 1 (2016), Pagination: 21-26Abstract
Two simple, precise, economical, fast and reliable UV methods have been developed for the simultaneous estimation of Paracetamol and Domperidone in bulk and pharmaceutical dosage form. Method A is Absorbance maxima method, which is based on measurement of absorption at maximum wavelength of 248 nm and 286 nm for Paracetamol and Domperidone respectively. Method B is area under curve (AUC), in the wavelength range of 220-274 nm for Paracetamol and 262-304 nm for Domperidone. Linearity for detector response was observed in the concentration range of 5-25 μg/ml for Paracetamol and 5-25 μg/ml for Domperidone. The accuracy of the methods was assessed by recovery studies and was found to be 100.11 % and 102.04 % for Paracetamol and 99.10 % and 100.52 % Domperidone by using method A and B respectively. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The results were validated statistically as per ICH Q2 R1guideline and were found to be satisfactory. The proposed methods were successfully applied for the determination of for Paracetamol and Domperidone in commercial pharmaceutical dosage form.Keywords
Paracetamol, Domperidone, Simultaneous Estimation, Area under Curve, Precision, Absorbance Maxima Method.- An Updated Review on Current Situation of Corona Virus Disease
Abstract Views :68 |
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Authors
Affiliations
1 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
3 Internal Medicine SAIL Hospital, Durgapur - 713216, West Bengal, IN
1 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
3 Internal Medicine SAIL Hospital, Durgapur - 713216, West Bengal, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 2 (2022), Pagination: 167-175Abstract
COVID-19 is currently regarded as a lethal disease. COVID-19 has exaggerated over 2.5 million citizen’s universal, consequential into more than 170,000 confirmed cases deaths Very recently a novel corona virus, SARS-CoV-2, was identified because of causal cause of an outbreak of viral pneumonia centered around Wuhan, Hubei, China in Dec 2019, now called as COVID-19. The corona disease infection 2019 (Covid-19) (2019- nCoV) pandemic is an international public health emergency with major social and economic disruptions and devastating health consequences. COVID-19 is also known as a pandemic. COVID-19 has infected over 2.5 million people around the world, resulting in over 170,000 deaths. The rapid development of vaccines is imperative. Corona viruses are a group of related RNA viruses that cause diseases in mammals and birds. It triggers breathing zones that can vary from moderate to fatal in humans and birds more than a few issues to ordinary frosty (so as to can also be affected via different pathogens, mostly rhinoviruses) are mild, while more deadly strains be able to reason SARS, MERS, and COVID-19 in humans. Thousands of illnesses and deaths have occurred as a result of the disease. In fact, none exact cure remains available for the disorder yet this demands that even the condition should not expand. Notable Isolation of sick people, adequate ventilation, hand washing, and the utilization of PPE Kit are also preventive measures. As a result, this paper covers all aspects of COVID-19, including epidemiology, transmission, clinical characteristics, diagnosis, treatment, and prevention.
Keywords
Covid-19, SARS, Pandemic, MERS, Corona Virus, Viral PneumoniaReferences
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- In-vitro, In-vivo Evaluation of Floating Tablets of Clarithromycin
Abstract Views :67 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 3 (2022), Pagination: 225-231Abstract
The main purpose of this research work was to design and process optimization of oral floating drug delivery system of Clarithromycin floating tablets by using the hydrophilic polymer Hydroxylpropyl methyl cellulose and gas generating agent sodium bicarbonate and citric acid. A 32 randomized full factorial design was used to study. In this design 2 factors were evaluated, each at 3 levels and experimental trials were performed at all 9 possible combinations. The independent and dependent variables are selected for optimization study. The radio-labelled floating tablets were prepared by adding barium sulphate in the optimized formulations for in- vivo radiographic study. The Results of multiple regression analysis indicated that both factors X1 and X2 significantly affected on the dependent parameters. The formulation was optimized on the basis of floating ability and in-vitro drug release. It should be concluded that as the time increases, the swelling index was increased, because weight gain by tablet was increased proportionally with rate of hydration. In-vivo radiographic studies of the optimized formulations were performed using New Zeal Albino rabbits by X-ray imaging technique. The in-vivo X-ray imaging and radiographic studies clearly indicated that the prepared optimized floating tablets were retained in the rabbit stomach over a prolonged period of time and had good in-vivo performance. Radiological evidences suggest that the formulated floating tablets of antibiotics were well floated more than 6 h in rabbit stomach.Keywords
In-vivo Radiographic Studies, In-vivo Performance, New Zeal Albino Rabbits, Clarithromycin Floating TabletsReferences
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- Patel V. F., Patel N. M. Intragastric Floating Drug Delivery System of Cefuroxime Axetil: In Vitro Evaluation. AAPS Pharm. Sci. Tech. 2006; 7(1): 118-124.
- Drug Bank: https://go.drugbank.com/salts/DBSALT002306.
- Sonar G. S. Jain D. K. Preparation and in-vitro evaluation of bilayer and floating bioadhesive tablets of rosiglitazone meleate. J. Pharm. Sci. 2007; 2(4): 161-169.
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- Basak S.C, Rao N. Development and in-vitro evaluation of an oral floating matrix tablet formulation of ciprofloxacin. Indian J. Pharm. Sci. 2004; 66(3): 313-316.
- Gambhire M. N. Development and in-vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS Pharm. Sci. Tech. 2007; 8(3): E1-E9.
- Patel V. F., Patel N. M. Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets. Drug Dev. Ind. Pharm. 2007; 33(3): 327-334.
- Anilkumar J. Shinde, Arun N. Waghule, Manoj B. Paithane, Harinath N. More. Formulation and in-vitro evaluation of sustained release floating tablet of cephalexin using hydrophilic polymers. Int. J. Pharm. Sci. 2010; 2(2):58-65.
- Martindale, the Complete Drug Reference. Sweetman Sean C., Blake P. S. 34th Edition Pharmaceutical Press London. 2005; 192-193, 155-156 and 168.
- Sutar R., Masareddy R. et al. hydrodynamically balanced tablets of Clarithromycin. Res. J. Pharma. Biol. Chem. Sci. 2010; 1(3): 284.
- Putta R. K., Hiremath D. et al. Design and evaluation studies on novel floating tablets for peptic ulcer treatment. J. Adv. Pharm. Edu. Res. 2011; 2: 159-176.
- Singh P. K., Kumar S. et al. Formulation Development and Evaluation of Clarithromycin oral Dosage form. Int. Res. J. Pharm. 2012; 3(4): 281-287.
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- An Overview on Mini Tablets
Abstract Views :66 |
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Authors
Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
2 Department of Quality Assurance, Sahyadri College of Pharmacy, Methwade, Sangola - 413307, Solapur, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 3 (2022), Pagination: 266-271Abstract
Mini Tablets are solid dosage forms with a diameter <= 3 mm and separated into subunits of conventional tablets. Production methods are similar to standard tablets, but the only difference is the use of multiple punches. They have advantageous for use in patients suffering from swallowing difficulty and receiving multiple drug treatment. They provide a more effective treatment by reducing the fluctuation in the drug’s release profile. At the same time, different release systems can be used together. In addition, Mini Tablets have a number of advantages over single unit dosage forms, and in recent years the prominence continues to increase. In the light of this information, the advantages and disadvantages of mini tablets, production equipment, formulation designs, different emission characteristics and evaluation criteria are emphasized in this compilation. Mini tablets represent a new trend in solid dosage form design, with the main goal of overcoming some therapeutic obstacles. Mini tablets are multiple unit dosage forms and are advantageous than pellets or any other oral dosage forms as they are easy to manufacture and stability problems are less.Keywords
Mini Tablets, Solid Dosage Form, Oral Drug Delivery, Sustained ReleaseReferences
- Hellebechgaard and gydahegermannnielsen. Controlled-release multiple-units and single-unit doses a literature review. Drug Development and Industrial Pharmacy, 1978; 4(1): 53-67.
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